Molecular mechanisms of anticancer activities of polyphyllin VII.
Chem Biol Drug Des
; 97(4): 914-929, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33342040
ABSTRACT
Cancer is the leading cause of mortality in the world. The major therapies for cancer treatment are chemotherapy, surgery, and radiation therapy. All these therapies expensive, toxic and show resistance. The plant-derived compounds are considered safe, cost-effective and target cancer through different pathways. In these pathways include oxidative stress, mitochondrial dependent and independent, STAT3, NF-kB, MAPKs, cell cycle, and autophagy pathways. One of the new plants derived compounds is Polyphyllin VII (PPVII), which target cancer through different molecular mechanisms. In literature, there is a review gap of studies on PPVII; therefore in the current review, we summarized the available studies on PPVII to provide a base for future research.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Apoptose
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
Chem Biol Drug Des
Ano de publicação:
2021
Tipo de documento:
Article