Genetic susceptibilities and prediction modeling of carbamazepine and allopurinol-induced severe cutaneous adverse reactions in Vietnamese.
Pharmacogenomics
; 22(1): 1-12, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33356553
ABSTRACT
Aims:
To determine genetic susceptibility markers for carbamazepine (CBZ) and allopurinol-induced severe cutaneous adverse reactions (SCARs) in Vietnamese.Methods:
A case-control study was performed involving 122 patients with CBZ or allopurinol-induced SCARs and 120 drug tolerant controls.Results:
HLA-B*5801 was strongly associated with allopurinol-induced SCARs and strongly correlated with SNP rs9263726. HLA-B*1502 was associated with CBZ-induced Stevens-Johnson syndrome/toxic epidermal necrolysis but not with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. No association was found between HLA-A*3101 and CBZ-induced SCARs. HLA-B*5801 and rs3909184 allele A with renal insufficiency were shown to increase the risk of allopurinol-induced SCARs.Conclusion:
HLA-B*5801 and HLA-B*1502 confer susceptibility to allopurinol-induced SCARs and CBZ-induced SJS/TEN in Vietnamese. SNP rs9263726 can be used as a surrogate marker in identifying HLA-B*5801.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbamazepina
/
Antígenos HLA-B
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Alopurinol
/
Síndrome de Stevens-Johnson
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Predisposição Genética para Doença
/
Povo Asiático
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Pharmacogenomics
Ano de publicação:
2021
Tipo de documento:
Article