Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction.

Juni, Rio P; Al-Shama, Rushd; Kuster, Diederik W D; van der Velden, Jolanda; Hamer, Henrike M; Vervloet, Marc G; Eringa, Etto C; Koolwijk, Pieter; van Hinsbergh, Victor W M

Juni, Rio P; Al-Shama, Rushd; Kuster, Diederik W D; van der Velden, Jolanda; Hamer, Henrike M; Vervloet, Marc G; Eringa, Etto C; Koolwijk, Pieter; van Hinsbergh, Victor W M.

Afiliação

Juni RP; Department of Physiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Al-Shama R; Department of Physiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Kuster DWD; Department of Physiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
van der Velden J; Department of Physiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Hamer HM; Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Vervloet MG; Department of Nephrology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Eringa EC; Department of Physiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands; Department of Physiology, Maastricht University, Maastricht, The Netherlands.
Koolwijk P; Department of Physiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
van Hinsbergh VWM; Department of Physiology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands. Electronic address: v.vanhinsbergh@amsterdamumc.nl.

Kidney Int ; 99(5): 1088-1101, 2021 05.

Article em En | MEDLINE | ID: mdl-33359500

Assuntos

Miócitos Cardíacos; Insuficiência Renal Crônica; Animais; Compostos Benzidrílicos; Células Endoteliais; Endotélio; Endotélio Vascular; Glucosídeos; Humanos; Óxido Nítrico; Ratos; Insuficiência Renal Crônica/tratamento farmacológico

Palavras-chave

cardiomyocyte relaxation and contraction; chronic kidney disease; empagliflozin; endothelium-to-cardiomyocyte crosstalk; heart failure; mitochondrial oxidative damage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Insuficiência Renal Crônica Limite: Animals / Humans Idioma: En Revista: Kidney Int Ano de publicação: 2021 Tipo de documento: Article

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