Your browser doesn't support javascript.
loading
Unorthodox Transcriptional Mechanisms of Lipid-Sensing Nuclear Receptors in Macrophages: Are We Opening a New Chapter?
Czimmerer, Zsolt; Halasz, Laszlo; Nagy, Laszlo.
Afiliação
  • Czimmerer Z; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Halasz L; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States.
  • Nagy L; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Front Endocrinol (Lausanne) ; 11: 609099, 2020.
Article em En | MEDLINE | ID: mdl-33362723
ABSTRACT
Work over the past 30 years has shown that lipid-activated nuclear receptors form a bridge between metabolism and immunity integrating metabolic and inflammatory signaling in innate immune cells. Ligand-induced direct transcriptional activation and protein-protein interaction-based transrepression were identified as the most common mechanisms of liganded-nuclear receptor-mediated transcriptional regulation. However, the integration of different next-generation sequencing-based methodologies including chromatin immunoprecipitation followed by sequencing and global run-on sequencing allowed to investigate the DNA binding and ligand responsiveness of nuclear receptors at the whole-genome level. Surprisingly, these studies have raised the notion that a major portion of lipid-sensing nuclear receptor cistromes are not necessarily responsive to ligand activation. Although the biological role of the ligand insensitive portion of nuclear receptor cistromes is largely unknown, recent findings indicate that they may play roles in the organization of chromatin structure, in the regulation of transcriptional memory, and the epigenomic modification of responsiveness to other microenvironmental signals in macrophages. In this review, we will provide an overview and discuss recent advances of our understanding of lipid-activated nuclear receptor-mediated non-classical or unorthodox actions in macrophages.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Citoplasmáticos e Nucleares / Metabolismo dos Lipídeos / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Citoplasmáticos e Nucleares / Metabolismo dos Lipídeos / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Ano de publicação: 2020 Tipo de documento: Article