A Population Pharmacokinetic Model of (R)- and (S-) Oxybutynin and Its Active Metabolites After Oral and Intravesical Administration to Healthy Volunteers.

Kretschmar, Melanie; Suleiman, Ahmed Abbas; Krause, Petra; Albrecht, Uwe; Stein, Raimund; Rubenwolf, Peter; Fuhr, Uwe; Taubert, Max

Kretschmar, Melanie; Suleiman, Ahmed Abbas; Krause, Petra; Albrecht, Uwe; Stein, Raimund; Rubenwolf, Peter; Fuhr, Uwe; Taubert, Max.

Afiliação

Kretschmar M; Department I of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Cologne, Germany.
Suleiman AA; Department I of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Cologne, Germany.
Krause P; Department of Cardiothoracic Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Heart Center, Cologne, Germany.
Albrecht U; Mediconomics GmbH, Hannover, Germany.
Stein R; Department of Pediatric, Adolescent and Reconstructive Urology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Rubenwolf P; Department of Urology, Frankfurt University Medical Center, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
Fuhr U; Department I of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Cologne, Germany.
Taubert M; Department I of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Cologne, Germany.

J Clin Pharmacol ; 61(7): 961-971, 2021 07.

Article em En | MEDLINE | ID: mdl-33368382

Assuntos

Antagonistas Colinérgicos/química; Antagonistas Colinérgicos/farmacocinética; Ácidos Mandélicos/química; Ácidos Mandélicos/farmacocinética; Administração Intravesical; Administração Oral; Área Sob a Curva; Antagonistas Colinérgicos/administração & dosagem; Relação Dose-Resposta a Droga; Voluntários Saudáveis; Humanos; Ácidos Mandélicos/administração & dosagem; Ácidos Mandélicos/metabolismo; Taxa de Depuração Metabólica; Modelos Biológicos

Palavras-chave

anticholinergics; overactive bladder; pharmacometrics; population pharmacokinetic modeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antagonistas Colinérgicos / Ácidos Mandélicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Clin Pharmacol Ano de publicação: 2021 Tipo de documento: Article

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