Self-Assembling Derivative of Hydrocortisone as Glucocorticoid Receptor-Targeted Nanotherapeutics for Synergistic, Combination Therapy against Colorectal Tumor.

Sridharan, Kathyayani; Rathore, Bhowmira; Yousuf, Md; Reddy Rachamalla, Hari Krishna; Jinka, Sudhakar; Jaggarapu, Madhan Mohan Chandra Sekhar; Banerjee, Rajkumar

Sridharan, Kathyayani; Rathore, Bhowmira; Yousuf, Md; Reddy Rachamalla, Hari Krishna; Jinka, Sudhakar; Jaggarapu, Madhan Mohan Chandra Sekhar; Banerjee, Rajkumar.

Afiliação

Sridharan K; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Rathore B; Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Ghaziabad 201002, India.
Yousuf M; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Reddy Rachamalla HK; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Jinka S; Department of Chemistry, Ramnagar College, Purba Medinipur, West Bengal 721 453, India.
Jaggarapu MMCS; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Banerjee R; Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Ghaziabad 201002, India.

Mol Pharm ; 18(3): 1208-1228, 2021 03 01.

Article em En | MEDLINE | ID: mdl-33371687

Assuntos

Antineoplásicos/farmacologia; Neoplasias Colorretais/tratamento farmacológico; Hidrocortisona/farmacologia; Receptores de Glucocorticoides/metabolismo; Células A549; Animais; Apoptose/efeitos dos fármacos; Células CHO; Linhagem Celular; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Neoplasias Colorretais/metabolismo; Cricetulus; Docetaxel/farmacologia; Doxorrubicina/farmacologia; Sinergismo Farmacológico; Feminino; Células HEK293; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Células NIH 3T3

Palavras-chave

colon cancer; drug sensitization; drug synergism; glucocorticoid receptor; hydrocortisone; targeted drug and gene delivery; vesicles

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Hidrocortisona / Neoplasias Colorretais / Receptores de Glucocorticoides / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: Mol Pharm Ano de publicação: 2021 Tipo de documento: Article

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