Novel GABAA Agonist Entities: Pharmacological Investigation and Molecular Modeling Study of Thiazolo- and Thiadiazolo-[3,2-a][1,3]diazepine Analogs.
Mini Rev Med Chem
; 21(9): 1048-1057, 2021.
Article
em En
| MEDLINE
| ID: mdl-33390131
ABSTRACT
Thiazolo- and thiadiazolo-[3,2-a][1,3]diazepines and their patented derivatives, tested with diverse CNS pharmacological activities, constitute an important class of compounds for new drug development. Therefore, research efforts were continued to design, synthesize, and evaluate compounds for their ultra-short, short-acting hypnotic, anticonvulsant, and neuromuscular blocking activities. The present review provides a summary of the work accomplished by these heterocycles and their biological evaluation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azepinas
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Tiazóis
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Receptores de GABA-A
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Agonistas de Receptores de GABA-A
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Anticonvulsivantes
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Bloqueadores Neuromusculares
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mini Rev Med Chem
Ano de publicação:
2021
Tipo de documento:
Article