Promising Therapy for Heart Failure in Patients with Severe COVID-19: Calming the Cytokine Storm.
Cardiovasc Drugs Ther
; 35(2): 231-247, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33404925
ABSTRACT
The coronavirus disease 19 (COVID-19) pandemic poses a serious global threat to human health and the economy. Based on accumulating evidence, its continuous progression involves not only pulmonary injury but also damage to the cardiovascular system due to intertwined pathophysiological risks. As a point of convergence in the pathophysiologic process between COVID-19 and heart failure (HF), cytokine storm induces the progression of COVID-19 in patients presenting pre-existing or new onset myocardial damage and even HF. Cytokine storm, as a trigger of the progression of HF in patients with COVID-19, has become a novel focus to explore therapies for target populations. In this review, we briefly introduce the basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and illuminate the mechanism and links among COVID-19, cytokine storm, and HF. Furthermore, we discuss drugs and therapeutic targets for patients with COVID-19 and HF.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Síndrome da Liberação de Citocina
/
SARS-CoV-2
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COVID-19
/
Insuficiência Cardíaca
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Cardiovasc Drugs Ther
Ano de publicação:
2021
Tipo de documento:
Article