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Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum.
Kim, Kyoung Min; Hussein, Usama Khamis; Park, See-Hyoung; Moon, Young Jae; Zhang, Zhongkai; Ahmed, Asmaa Gamal; Ahn, Ae-Ri; Park, Ho Sung; Kim, Jung Ryul; Jang, Kyu Yun.
Afiliação
  • Kim KM; Department of Pathology, Jeonbuk National University Medical School, 567 Baekje-daero, Dukjin-gu, Jeonju, 54896, Republic of Korea.
  • Hussein UK; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical, Research Institute of Jeonbuk National University Hospital and Research Institute for Endocrine Sciences, Jeonju, Republic of Korea.
  • Park SH; Department of Pathology, Jeonbuk National University Medical School, 567 Baekje-daero, Dukjin-gu, Jeonju, 54896, Republic of Korea.
  • Moon YJ; Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
  • Zhang Z; Department of Bio and Chemical Engineering, Hongik University, Sejong, Republic of Korea.
  • Ahmed AG; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical, Research Institute of Jeonbuk National University Hospital and Research Institute for Endocrine Sciences, Jeonju, Republic of Korea.
  • Ahn AR; Department of Biochemistry and Molecular Biology, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Park HS; Department of Orthopedic Surgery, Jeonbuk National University Medical School, 567 Baekje-daero, Dukjin-gu, Jeonju, 54896, Republic of Korea.
  • Kim JR; Department of Pathology, Jeonbuk National University Medical School, 567 Baekje-daero, Dukjin-gu, Jeonju, 54896, Republic of Korea.
  • Jang KY; Faculty of Postgraduate Studies and Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt.
Diagn Pathol ; 16(1): 2, 2021 Jan 09.
Article em En | MEDLINE | ID: mdl-33419470
ABSTRACT

BACKGROUND:

IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, IL4Rα and IL13Rα1 were reported to have roles in cancer progression and suggested as potential prognostic markers. However, studies on IL4Rα and IL13Rα1 in soft-tissue sarcomas have been limited.

METHODS:

This study investigated the immunohistochemical expression of IL4Rα and IL13Rα1 in 89 soft-tissue sarcomas of the extremities, superficial trunk, and retroperitoneum. Immunohistochemical staining for IL4Rα and IL13Rα1 were scored according to a combination of staining intensity and staining area in tissue microarray samples. Positivity for the immunohistochemical expression of IL4Rα and IL13Rα1 were determined using receiver operating curve analysis. Statistical analysis was performed using regression analysis and a chi-square test.

RESULTS:

In human soft-tissue sarcomas, immunohistochemical expression of IL4Rα was significantly associated with IL13Rα1 expression. Nuclear and cytoplasmic expression of IL4Rα and IL13Rα1 were significantly associated with shorter survival of soft-tissue sarcoma patients in univariate analysis. Multivariate analysis indicated that nuclear expression of IL4Rα and IL13Rα1 were independent indicators of shorter overall survival (IL4Rα; p = 0.002, IL13Rα1; p = 0.016) and relapse-free survival (IL4Rα; p = 0.022, IL13Rα1; p < 0.001) of soft-tissue sarcoma patients. Moreover, the co-expression pattern of nuclear IL4Rα and IL13Rα1 was an independent indicator of shorter survival of soft-tissue sarcoma patients (overall survival; overall p < 0.001, relapse-free survival; overall p < 0.001).

CONCLUSIONS:

This study suggests IL4Rα and IL13Rα1 are associated with the progression of soft-tissue sarcoma, and the expression of IL4Rα and IL13Rα1 might be novel prognostic indicators of soft-tissue sarcoma patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retroperitoneais / Sarcoma / Neoplasias de Tecidos Moles / Subunidade alfa de Receptor de Interleucina-4 / Subunidade alfa1 de Receptor de Interleucina-13 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Diagn Pathol Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retroperitoneais / Sarcoma / Neoplasias de Tecidos Moles / Subunidade alfa de Receptor de Interleucina-4 / Subunidade alfa1 de Receptor de Interleucina-13 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Diagn Pathol Ano de publicação: 2021 Tipo de documento: Article