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TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Ochiiwa, Hiroaki; Ailiken, Guzhanuer; Yokoyama, Masataka; Yamagata, Kazuyuki; Nagano, Hidekazu; Yoshimura, Chihoko; Muraoka, Hiromi; Ishida, Keiji; Haruma, Tomonori; Nakayama, Akitoshi; Hashimoto, Naoko; Murata, Kazutaka; Nishimura, Motoi; Kawashima, Yusuke; Ohara, Osamu; Ohkubo, Shuichi; Tanaka, Tomoaki.
Afiliação
  • Ochiiwa H; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba, Ibaraki, 300-2611, Japan.
  • Ailiken G; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
  • Yokoyama M; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
  • Yamagata K; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
  • Nagano H; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
  • Yoshimura C; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba, Ibaraki, 300-2611, Japan.
  • Muraoka H; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba, Ibaraki, 300-2611, Japan.
  • Ishida K; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba, Ibaraki, 300-2611, Japan.
  • Haruma T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba, Ibaraki, 300-2611, Japan.
  • Nakayama A; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
  • Hashimoto N; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
  • Murata K; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
  • Nishimura M; Division of Laboratory Medicine, Clinical Genetics and Proteomics, Chiba University Hospital, Chiba, 260-8670, Japan.
  • Kawashima Y; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Chiba, 292-0818, Japan.
  • Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Chiba, 292-0818, Japan.
  • Ohkubo S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba, Ibaraki, 300-2611, Japan. s-ohkubo@taiho.co.jp.
  • Tanaka T; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan. tomoaki@restaff.chiba-u.jp.
Oncogene ; 40(7): 1217-1230, 2021 02.
Article em En | MEDLINE | ID: mdl-33420360
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas c-myc / Proteínas Proto-Oncogênicas c-bcl-2 / Proteína NEDD8 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncogene Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas c-myc / Proteínas Proto-Oncogênicas c-bcl-2 / Proteína NEDD8 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncogene Ano de publicação: 2021 Tipo de documento: Article