Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis.

Yan, Jun; Yu, Jing; Yuan, Shunzong; Tang, Wanqi; Ma, Wei; Yang, Xue; Liu, Yijia; Liang, Huaping; Zhong, Xuemei; Shao, Jing; Cao, Yang; Mao, Changchuin; Near, Richard; Gao, Wenda

Yan, Jun; Yu, Jing; Yuan, Shunzong; Tang, Wanqi; Ma, Wei; Yang, Xue; Liu, Yijia; Liang, Huaping; Zhong, Xuemei; Shao, Jing; Cao, Yang; Mao, Changchuin; Near, Richard; Gao, Wenda.

Afiliação

Yan J; Institute of Surgery Research, Army Medical University, Chongqing, China.
Yu J; Institute of Surgery Research, Army Medical University, Chongqing, China.
Yuan S; The 5th Medical Center of PLA General Hospital, Beijing, China.
Tang W; Institute of Surgery Research, Army Medical University, Chongqing, China.
Ma W; Institute of Surgery Research, Army Medical University, Chongqing, China.
Yang X; Institute of Surgery Research, Army Medical University, Chongqing, China.
Liu Y; Institute of Surgery Research, Army Medical University, Chongqing, China.
Liang H; Institute of Surgery Research, Army Medical University, Chongqing, China.
Zhong X; Boston University Medical Center, Boston, USA.
Shao J; Antagen (Beijing) Biotechnologies, Co. Ltd, Beijing, China.
Cao Y; Antagen (Beijing) Biotechnologies, Co. Ltd, Beijing, China.
Mao C; Boston University Medical Center, Boston, USA.
Near R; Antagen Institute for Biomedical Research, Boston, USA.
Gao W; Boston University Medical Center, Boston, USA.

Eur J Immunol ; 51(4): 995-998, 2021 04.

Article em En | MEDLINE | ID: mdl-33448336

ABSTRACT

ABSTRACT

Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC-/- mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC-/- mice by IL-22 antagonism suggests the existence of MSCIL-22 regulatory axis.

Assuntos

Fatores de Transcrição Hélice-Alça-Hélice Básicos/imunologia; Colite/imunologia; Citocinas/imunologia; Mediadores da Inflamação/imunologia; Interleucinas/imunologia; Linfócitos/imunologia; Células Th17/imunologia; Animais; Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Colite/induzido quimicamente; Colite/genética; Citocinas/metabolismo; Sulfato de Dextrana; Imunidade Inata/imunologia; Mediadores da Inflamação/metabolismo; Interleucina-17/imunologia; Interleucina-17/metabolismo; Interleucinas/genética; Interleucinas/metabolismo; Linfócitos/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Células Th17/metabolismo; Interleucina 22

Palavras-chave

IL-22; ILC3; Musculin; Th17; Transcription factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Citocinas / Interleucinas / Colite / Mediadores da Inflamação / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Células Th17 Limite: Animals Idioma: En Revista: Eur J Immunol Ano de publicação: 2021 Tipo de documento: Article

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