Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics.
Eur Spine J
; 30(8): 2231-2237, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-33452926
ABSTRACT
PURPOSE:
To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls.METHODS:
In this observational retrospective study, T2-weighted sagittal MRI images (n = 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2-L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels, n = 69 males) and VDR variables.RESULTS:
Males showed higher BMI and total MRI score than females. Patients bearing TT compared to tt VDR genotypes showed significant higher total MRI scores. Among males (n = 125), TT, bb and aa genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (n = 69 males).CONCLUSIONS:
The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Lombar
/
Degeneração do Disco Intervertebral
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur Spine J
Ano de publicação:
2021
Tipo de documento:
Article