Efficacy of novel bispecific antibody targeting TNF-&#945;/CXCL10 in the treatment of experimental arthritis.

Kang, Shin Eui; Park, Jin Kyun; Yoo, Hyun Jung; Kang, Heun-Soo; Park, Young Woo; Park, Bum-Chan; Park, Jae-Eun; Lee, Eun Young; Lee, Eun Bong; Song, Yeong Wook

Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis.

Kang, Shin Eui; Park, Jin Kyun; Yoo, Hyun Jung; Kang, Heun-Soo; Park, Young Woo; Park, Bum-Chan; Park, Jae-Eun; Lee, Eun Young; Lee, Eun Bong; Song, Yeong Wook.

Afiliação

Kang SE; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National Unive
Park JK; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Yoo HJ; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National Unive
Kang HS; Cell2in,Inc., Seoul, Republic of Korea.
Park YW; Y-Biologics, Daejeon, Republic of Korea.
Park BC; Y-Biologics, Daejeon, Republic of Korea.
Park JE; Y-Biologics, Daejeon, Republic of Korea.
Lee EY; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Lee EB; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Song YW; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National Unive

Transl Res ; 232: 75-87, 2021 06.

Article em En | MEDLINE | ID: mdl-33453429

Assuntos

Anticorpos Biespecíficos/uso terapêutico; Artrite Experimental/terapia; Artrite Reumatoide/terapia; Quimiocina CXCL10/imunologia; Fator de Necrose Tumoral alfa/imunologia; Adalimumab; Animais; Anticorpos Biespecíficos/química; Anticorpos Biespecíficos/genética; Quimiocina CXCL10/antagonistas & inibidores; Clonagem Molecular; Cruzamentos Genéticos; Humanos; Fragmentos Fc das Imunoglobulinas; Fatores Imunológicos; Imunoterapia/métodos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos NOD; Camundongos Transgênicos; Anticorpos de Cadeia Única; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Fator de Necrose Tumoral alfa/genética

Palavras-chave

ADAâ¯=â¯adalimumab; ANOVAâ¯=â¯analysis of variance; BsAbâ¯=â¯bispecific antibody; CXCL10â¯=â¯C-X-C motif chemokine 10; FLSâ¯=â¯fibroblast-like synoviocytes; GAPDHâ¯=â¯glyceraldehyde 3-phosphate dehydrogenase; H&Eâ¯=â¯hematoxylin and eosin; IC(50)â¯=â¯the half-maximal inhibitory concentration; ILâ¯=â¯interleukin; Kdâ¯=â¯dissociation constants; LPSâ¯=â¯lipopolysaccharide; Mwâ¯=â¯molecular weight; O.D.â¯=â¯optical density; PBMCsâ¯=â¯peripheral blood mononuclear cells; PBSâ¯=â¯phosphate-buffered saline; RANKLâ¯=â¯receptor activator of nuclear factor kappa-B ligand; RAâ¯=â¯rheumatoid arthritis; SEMâ¯=â¯standard error of the mean; SPRâ¯=â¯surface plasmon resonance; ScFvâ¯=â¯single-chain variable fragment; TNF-αâ¯=â¯tumor necrosis factor-α; TRAPâ¯=â¯tartrate-resistant acid phosphatase; Tg mouseâ¯=â¯transgenic mouse; VHâ¯=â¯variable heavy chain; VLâ¯=â¯variable light chain; bDMARDsâ¯=â¯biological disease-modifying anti-rheumatic drugs; cDNAâ¯=â¯complementary DNA; qPCRâ¯=â¯quantitative real-time polymerase chain reaction

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Artrite Experimental / Artrite Reumatoide / Fator de Necrose Tumoral alfa / Anticorpos Biespecíficos / Quimiocina CXCL10 Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Transl Res Ano de publicação: 2021 Tipo de documento: Article

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