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Fatal pyrrolizidine alkaloid poisoning of infants caused by adulterated Senecio coronatus.
Van Schalkwyk, F J; Stander, M A; Nsizwane, M; Mathee, A; Van Wyk, B-E.
Afiliação
  • Van Schalkwyk FJ; Mass Spectrometry Unit, Central Analytical Facility, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa.
  • Stander MA; Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa; Mass Spectrometry Unit, Central Analytical Facility, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa.
  • Nsizwane M; Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, Johannesburg, South Africa.
  • Mathee A; Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, Johannesburg, South Africa.
  • Van Wyk BE; Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, Johannesburg, South Africa. Electronic address: bevanwyk@uj.ac.za.
Forensic Sci Int ; 320: 110680, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33461004
ABSTRACT
Senecio coronatus (known as izonkozonko and ubulibazi in Zulu) is commonly used in traditional medicine in South Africa as purification purgative and enemas for infants during weaning. We show for the first time that this species does not contain pyrrolizidine alkaloids and that reported cases of fatal hepatic sinusoidal obstruction syndrome in infants were caused by wrongly identified Senecio species containing large amounts of retrorsine-N-oxide. A validated ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection and quantitation of pyrrolizidine alkaloids is described.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides de Pirrolizidina / Senécio / Medicinas Tradicionais Africanas Limite: Humans / Infant País/Região como assunto: Africa Idioma: En Revista: Forensic Sci Int Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides de Pirrolizidina / Senécio / Medicinas Tradicionais Africanas Limite: Humans / Infant País/Região como assunto: Africa Idioma: En Revista: Forensic Sci Int Ano de publicação: 2021 Tipo de documento: Article