The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a <i>purR</i> Mutant by the Increased Production of SarA and Decreased Production of Extracellular Proteases.

Alkam, Duah; Jenjaroenpun, Piroon; Ramirez, Aura M; Beenken, Karen E; Spencer, Horace J; Smeltzer, Mark S

The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a purR Mutant by the Increased Production of SarA and Decreased Production of Extracellular Proteases.

Alkam, Duah; Jenjaroenpun, Piroon; Ramirez, Aura M; Beenken, Karen E; Spencer, Horace J; Smeltzer, Mark S.

Afiliação

Alkam D; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Jenjaroenpun P; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Ramirez AM; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Beenken KE; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Spencer HJ; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Smeltzer MS; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA smeltzermarks@uams.edu.

Infect Immun ; 89(4)2021 03 17.

Article em En | MEDLINE | ID: mdl-33468580

Assuntos

Proteínas de Bactérias/biossíntese; Proteínas de Bactérias/genética; Endopeptidases/biossíntese; Mutação; Proteínas Repressoras/genética; Infecções Estafilocócicas/microbiologia; Staphylococcus aureus/fisiologia; Transativadores/biossíntese; Fatores de Virulência/genética; Animais; Biofilmes/crescimento & desenvolvimento; Elementos de DNA Transponíveis; Suscetibilidade a Doenças; Espaço Extracelular; Regulação Bacteriana da Expressão Gênica; Camundongos; Osteomielite/microbiologia; Staphylococcus aureus/patogenicidade; Virulência/genética

Palavras-chave

Staphylococcus aureus; extracellular proteases; osteomyelitis; purR; sarA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endopeptidases / Proteínas Repressoras / Infecções Estafilocócicas / Staphylococcus aureus / Proteínas de Bactérias / Transativadores / Fatores de Virulência / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Infect Immun Ano de publicação: 2021 Tipo de documento: Article

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