Novel boronium salt exhibits substantial antibacterial activity when compared to a commercial quaternary ammonium disinfectant.
Bioorg Med Chem Lett
; 36: 127808, 2021 03 15.
Article
em En
| MEDLINE
| ID: mdl-33482293
ABSTRACT
Commercial disinfectants are routinely used to decontaminate surfaces where microbes are expected and unwelcome. Several disinfectants contain quaternary ammonium salts, or "quats", all being derived from ammonium. Quaternary alkyl dimethyl benzyl ammonium chloride or bromide disinfectants are widely available. These compounds are effective in reducing or eliminating bacteria on contaminated nonporous surfaces. A unique benzyl derived boronium salt with strong detergent action has been developed. It demonstrated 4-8X greater antibacterial activity against 3 different bacteria when compared to an equal concentration of a commercial quant disinfectant solution containing alkyl dimethyl benzyl ammonium chloride and alkyl dimethyl ethylbenzyl ammonium chloride. Antibacterial effectiveness of each agent was determined by the minimum inhibitory concentration (MIC) method.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Brometos
/
Desinfetantes
/
Compostos de Amônio Quaternário
/
Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2021
Tipo de documento:
Article