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Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis.
Chu, Zhaoxing; Xu, Qinlong; Zhu, Qihua; Ma, Xiaodong; Mo, Jiajia; Lin, Gaofeng; Zhao, Yan; Gu, Yuanfeng; Bian, Lincui; Shao, Li; Guo, Jing; Ye, Wenfeng; Li, Jiaming; He, Guangwei; Xu, Yungen.
Afiliação
  • Chu Z; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 21009, China; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Xu Q; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China; Department of Medicinal Chemistry, Anhui University of Chinese Medicine, Hefei, 230031, China.
  • Zhu Q; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 21009, China.
  • Ma X; Department of Medicinal Chemistry, Anhui University of Chinese Medicine, Hefei, 230031, China.
  • Mo J; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Lin G; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Zhao Y; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Gu Y; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Bian L; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Shao L; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Guo J; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Ye W; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Li J; Department of Medicinal Chemistry, Anhui University of Chinese Medicine, Hefei, 230031, China.
  • He G; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China. Electronic address: heguangwei@ahipi.com.
  • Xu Y; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 21009, China. Electronic address: xyg@cpu.edu.cn.
Eur J Med Chem ; 213: 113171, 2021 Mar 05.
Article em En | MEDLINE | ID: mdl-33482600
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Boro / Desenho de Fármacos / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Inibidores da Fosfodiesterase 4 Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Boro / Desenho de Fármacos / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Inibidores da Fosfodiesterase 4 Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article