&#945;-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.

Trudler, Dorit; Sanz-Blasco, Sara; Eisele, Yvonne S; Ghatak, Swagata; Bodhinathan, Karthik; Akhtar, Mohd Waseem; Lynch, William P; Piña-Crespo, Juan C; Talantova, Maria; Kelly, Jeffery W; Lipton, Stuart A

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.

Trudler, Dorit; Sanz-Blasco, Sara; Eisele, Yvonne S; Ghatak, Swagata; Bodhinathan, Karthik; Akhtar, Mohd Waseem; Lynch, William P; Piña-Crespo, Juan C; Talantova, Maria; Kelly, Jeffery W; Lipton, Stuart A.

Afiliação

Trudler D; Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037.
Sanz-Blasco S; Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121.
Eisele YS; Center for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Ghatak S; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037.
Bodhinathan K; Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037.
Akhtar MW; Neurodegenerative Disease Center, Scintillon Institute, San Diego, California 92121.
Lynch WP; Center for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Piña-Crespo JC; Center for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.
Talantova M; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272 and Brain Health Research Institute, Kent State University, Kent, Ohio 44242.
Kelly JW; Neuroscience Translational Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037.
Lipton SA; Center for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037.

J Neurosci ; 41(10): 2264-2273, 2021 03 10.

Article em En | MEDLINE | ID: mdl-33483428

Assuntos

Astrócitos/metabolismo; Ácido Glutâmico/metabolismo; Neurônios/metabolismo; Receptores de N-Metil-D-Aspartato/metabolismo; alfa-Sinucleína/metabolismo; Animais; Astrócitos/efeitos dos fármacos; Astrócitos/patologia; Células Cultivadas; Feminino; Hipocampo/metabolismo; Hipocampo/patologia; Humanos; Células-Tronco Pluripotentes Induzidas/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Doenças Neurodegenerativas/metabolismo; Doenças Neurodegenerativas/patologia; Neurônios/efeitos dos fármacos; Neurônios/patologia; Ratos; Ratos Sprague-Dawley; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Sinapses/metabolismo; Sinapses/patologia; alfa-Sinucleína/farmacologia

Palavras-chave

astrocytic glutamate; extrasynaptic NMDARs; synaptic damage; α-synuclein oligomers

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / Receptores de N-Metil-D-Aspartato / Ácido Glutâmico / Alfa-Sinucleína / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Neurosci Ano de publicação: 2021 Tipo de documento: Article

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