Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation.

Sharma, Anjaney; Gogoi, Prerana; Chandravanshi, Monika; Kanaujia, Shankar Prasad

Sharma, Anjaney; Gogoi, Prerana; Chandravanshi, Monika; Kanaujia, Shankar Prasad.

Afiliação

Sharma A; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Gogoi P; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Chandravanshi M; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Kanaujia SP; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.

J Biomol Struct Dyn ; 40(13): 6013-6026, 2022 08.

Article em En | MEDLINE | ID: mdl-33491574

Assuntos

Caspases; Água; Apoptose/fisiologia; Caspases/química; Caspases/metabolismo; Domínio Catalítico; Humanos; Inflamação

Palavras-chave

Apoptotic caspase; inflammatory caspase; invariant water molecules; molecular dynamics; protease; zymogen

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Água / Caspases Limite: Humans Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2022 Tipo de documento: Article

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