Silver-Catalysed Hydroarylation of Highly Substituted Styrenes.
Angew Chem Int Ed Engl
; 60(15): 8537-8541, 2021 Apr 06.
Article
em En
| MEDLINE
| ID: mdl-33493358
ABSTRACT
Hydroarylation is an effective strategy to rapidly increase the complexity of organic structures by transforming flat alkene moieties into three-dimensional frameworks. Many strategies have already been developed to achieve the hydroarylation of styrenes, however most of these reports examine the hydroarylation of unpolar, ß-mono- or ß-unsubstituted styrenes, while exploring mainly electron-rich benzene nucleophiles. Herein, we report a mild and general catalytic system for the selective hydroheteroarylation of multiply substituted styrenes and heteroaromatic styrenes. Mechanistic analysis of the reaction led to the discovery of commercially available 2,2'5',2''-terthiophene as a key reagent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2021
Tipo de documento:
Article