The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.

Wang, Chunxia; Wang, Chengliang; Ren, Liying; Chen, Shankang; Chen, Wen-Hua; Li, Yuhao

Wang, Chunxia; Wang, Chengliang; Ren, Liying; Chen, Shankang; Chen, Wen-Hua; Li, Yuhao.

Afiliação

Wang C; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: wangcx@smu.edu.cn.
Wang C; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Ren L; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chen S; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chen WH; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: whchen@smu.edu.cn.
Li Y; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Endocrinology and Metabolism Group, Sydney Institute of Health Sciences/Sydney Institute of Traditional Chinese Medicine, NSW 2000, Australia. Electronic address: yuhao@sitcm.edu.au.

Life Sci ; 270: 119037, 2021 Apr 01.

Article em En | MEDLINE | ID: mdl-33497738

Assuntos

Resistência à Insulina/fisiologia; Músculo Esquelético/metabolismo; Proteína Quinase C/metabolismo; Animais; Glucose/metabolismo; Transportador de Glucose Tipo 4/metabolismo; Quinase I-kappa B/metabolismo; Inflamação/metabolismo; Insulina/metabolismo; Proteínas Substratos do Receptor de Insulina/metabolismo; Masculino; NF-kappa B/metabolismo; Olanzapina/farmacologia; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação; Proteína Quinase C/fisiologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/fisiologia; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

AMP-activated protein kinase; Insulin signaling; NFκB; Olanzapine; Protein kinase D; Skeletal muscle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Quinase C / Resistência à Insulina / Músculo Esquelético Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2021 Tipo de documento: Article

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