Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes.
Nutrients
; 13(2)2021 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-33499378
ABSTRACT
Magnesium (Mg2+) deficiency is probably the most underestimated electrolyte imbalance in Western countries. It is frequent in obese patients, subjects with type-2 diabetes and metabolic syndrome, both in adulthood and in childhood. This narrative review aims to offer insights into the pathophysiological mechanisms linking Mg2+ deficiency with obesity and the risk of developing metabolic syndrome and type 2 diabetes. Literature highlights critical issues about the treatment of Mg2+ deficiency, such as the lack of a clear definition of Mg2+ nutritional status, the use of different Mg2+ salts and dosage and the different duration of the Mg2+ supplementation. Despite the lack of agreement, an appropriate dietary pattern, including the right intake of Mg2+, improves metabolic syndrome by reducing blood pressure, hyperglycemia, and hypertriglyceridemia. This occurs through the modulation of gene expression and proteomic profile as well as through a positive influence on the composition of the intestinal microbiota and the metabolism of vitamins B1 and D.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Síndrome Metabólica
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Diabetes Mellitus Tipo 2
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Microbioma Gastrointestinal
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Magnésio
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Obesidade
Limite:
Adult
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Child
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Humans
Idioma:
En
Revista:
Nutrients
Ano de publicação:
2021
Tipo de documento:
Article