Bacteriophage therapy for bone and joint infections.
Bone Joint J
; 103-B(2): 234-244, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33517726
ABSTRACT
Antibiotic resistance represents a threat to human health. It has been suggested that by 2050, antibiotic-resistant infections could cause ten million deaths each year. In orthopaedics, many patients undergoing surgery suffer from complications resulting from implant-associated infection. In these circumstances secondary surgery is usually required and chronic and/or relapsing disease may ensue. The development of effective treatments for antibiotic-resistant infections is needed. Recent evidence shows that bacteriophage (phages; viruses that infect bacteria) therapy may represent a viable and successful solution. In this review, a brief description of bone and joint infection and the nature of bacteriophages is presented, as well as a summary of our current knowledge on the use of bacteriophages in the treatment of bacterial infections. We present contemporary published in vitro and in vivo data as well as data from clinical trials, as they relate to bone and joint infections. We discuss the potential use of bacteriophage therapy in orthopaedic infections. This area of research is beginning to reveal successful results, but mostly in nonorthopaedic fields. We believe that bacteriophage therapy has potential therapeutic value for implant-associated infections in orthopaedics. Cite this article Bone Joint J 2021;103-B(2)234-244.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dispositivos de Fixação Ortopédica
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Próteses e Implantes
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Infecções Bacterianas
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Doenças Ósseas Infecciosas
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Artrite Infecciosa
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Infecções Relacionadas à Prótese
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Terapia por Fagos
Limite:
Humans
Idioma:
En
Revista:
Bone Joint J
Ano de publicação:
2021
Tipo de documento:
Article