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Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma.
Li, Yaxin; Orahoske, Cody M; Geldenhuys, Werner J; Bhattarai, Asmita; Sabbagh, Abboud; Bobba, Viharika; Salem, Fatma M; Zhang, Wenjing; Shukla, Girish C; Lathia, Justin D; Wang, Bingcheng; Su, Bin.
Afiliação
  • Li Y; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Orahoske CM; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Geldenhuys WJ; Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, United States.
  • Bhattarai A; Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Sabbagh A; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Bobba V; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Salem FM; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Zhang W; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Shukla GC; Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Lathia JD; Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
  • Wang B; Department of Molecular Medicine, Lerner Research Institute, Cleveland Clinic, and Case Comprehensive Cancer Center, Cleveland, Ohio 44195, United States.
  • Su B; Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, United States.
J Med Chem ; 64(3): 1570-1583, 2021 02 11.
Article em En | MEDLINE | ID: mdl-33523674
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Receptores Androgênicos / Glioblastoma / Proteínas de Choque Térmico HSP27 / Antagonistas de Androgênios Limite: Animals / Humans Idioma: En Revista: J Med Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Receptores Androgênicos / Glioblastoma / Proteínas de Choque Térmico HSP27 / Antagonistas de Androgênios Limite: Animals / Humans Idioma: En Revista: J Med Chem Ano de publicação: 2021 Tipo de documento: Article