Fragility of reward vs antifragility of defense brain systems in drug dependence.
Soc Neurosci
; 16(2): 145-152, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33529536
ABSTRACT
Drug dependence is a debilitating disorder, affecting 30 million people worldwide. In this short review we discuss about the plasticity changes in the reward and defense brain systems induced by early-life psychosocial stressful experiences. Such changes may render persons more vulnerable to illicit drugs use, facilitating behaviors of abuse and development of addiction. We propose that underlying plasticity changes render brain reward system as increasingly fragile because of tolerance and other physiological effects that reduce responsiveness with repeated use. In contrast, we propose that brain defense system makes maintain antifragile mechanisms that generate more robust responses with the prolonged consumption of drugs. Investigating the underlying mechanisms of these brain plasticity changes may advance the development of more efficacious pharmacologic and psychotherapeutic approaches to rehabilitate patients and more efficacious prevention policies to protect children from stressful experiences.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Recompensa
/
Transtornos Relacionados ao Uso de Substâncias
Limite:
Child
/
Humans
Idioma:
En
Revista:
Soc Neurosci
Ano de publicação:
2021
Tipo de documento:
Article