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Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production.
Wang, Yaochun; Yang, Yang; Wang, Meng; Wang, Shuhong; Jeong, Jong-Min; Xu, Long; Wen, Yankai; Emontzpohl, Christoph; Atkins, Constance Lynn; Duong, Kevin; Moreno, Nicolas F; Yuan, Xiaoyi; Hall, David R; Dar, Wasim; Feng, Dechun; Gao, Bin; Xu, Yong; Czigany, Zoltan; Colgan, Sean P; Bynon, J Steve; Akira, Shizuo; Brown, Jared M; Eltzschig, Holger K; Jacobsen, Elizabeth A; Ju, Cynthia.
Afiliação
  • Wang Y; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Yang Y; Center for Translational Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
  • Wang M; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Wang S; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Jeong JM; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Xu L; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Wen Y; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Emontzpohl C; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Atkins CL; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Duong K; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Moreno NF; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Yuan X; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Hall DR; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Dar W; Department of Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Feng D; Department of Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Gao B; Laboratory of Liver Disease, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
  • Xu Y; Laboratory of Liver Disease, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
  • Czigany Z; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Colgan SP; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
  • Bynon JS; Department of Surgery and Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen 52074, Germany.
  • Akira S; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Brown JM; Department of Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Eltzschig HK; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
  • Jacobsen EA; School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Ju C; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Sci Transl Med ; 13(579)2021 02 03.
Article em En | MEDLINE | ID: mdl-33536281
ABSTRACT
Eosinophils are a myeloid cell subpopulation that mediates type 2 T helper cell immune responses. Unexpectedly, we identified a rapid accumulation of eosinophils in 22 human liver grafts after hepatic transplantation. In contrast, no eosinophils were detectable in healthy liver tissues before transplantation. Studies with two genetic mouse models of eosinophil deficiency and a mouse model of antibody-mediated eosinophil depletion revealed exacerbated liver injury after hepatic ischemia and reperfusion. Adoptive transfer of bone marrow-derived eosinophils normalized liver injury of eosinophil-deficient mice and reduced hepatic ischemia and reperfusion injury in wild-type mice. Mechanistic studies combining genetic and adoptive transfer approaches identified a critical role of suppression of tumorigenicity (ST2)-dependent production of interleukin-13 by eosinophils in the hepatoprotection against ischemia-reperfusion-induced injury. Together, these data provide insight into a mechanism of eosinophil-mediated liver protection that could serve as a therapeutic target to improve outcomes of patients undergoing liver transplantation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Eosinófilos Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Eosinófilos Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Ano de publicação: 2021 Tipo de documento: Article