Glyceryl Monostearate based Solid Lipid Nanoparticles for Controlled Delivery of Docetaxel.
Curr Drug Deliv
; 18(9): 1368-1376, 2021.
Article
em En
| MEDLINE
| ID: mdl-33538673
ABSTRACT
BACKGROUND:
Solid lipid nanoparticles (SLNs) is the drug delivery system that has the capability to improve drug release at the desired tumor site. The aim of the present study is to develop glyceryl monostearate (GMS) based SLNs for the controlled delivery of docetaxel.METHODS:
Hot melt encapsulation (HME) method was employed avoiding the use of organic solvents and, therefore, regarded as green synthesis of SLNs.RESULTS:
Optimized DTX-SLNs showed desirable size (100 nm) with low poly dispersity index and excellent entrapment efficiency. Surface charge confirmed the stability of formulation. transmission electron microscope (TEM) analysis showed spherical shaped particles and fourier transform infrared microscopy (FTIR) revealed compatibility among formulation excipients. Differential scanning calorimeter (DSC) analysis revealed that the melting transition peak of optimized formulation was also greater than 40°C indicating that SLNs would be solid at body temperature. In-vitro release profile (68% in 24 hours) revealed the controlled release profile of DTX-SLNs, indicating lipophilic docetaxel drug was entrapped inside high melting point lipid core. Cytotoxicity study revealed that blank SLNs were found to be biocompatible while dose dependent cytotoxicity was shown by DTX-SLNs.CONCLUSION:
These studies suggest that DTX-SLNs have the potential for controlled delivery of docetaxel and improved therapeutic outcome.Palavras-chave
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Nanopartículas
Idioma:
En
Revista:
Curr Drug Deliv
Ano de publicação:
2021
Tipo de documento:
Article