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Neglecting Plasma Protein Binding in COVID-19 Patients Leads to a Wrong Interpretation of Lopinavir Overexposure.
Stanke-Labesque, Francoise; Concordet, Didier; Djerada, Zoubir; Bouchet, Stéphane; Solas, Caroline; Mériglier, Etienne; Bonnet, Fabrice; Mourvillier, Bruno; Ruiz, Stéphanie; Martin-Blondel, Guillaume; Epaulard, Olivier; Schwebel, Carole; Gautier-Veyret, Elodie; Gandia, Peggy.
Afiliação
  • Stanke-Labesque F; Laboratoire de Pharmacologie-Pharmacogénétique-Toxicologie, University of Grenoble Alpes, Inserm, CHU Grenoble Alpes, Grenoble, France.
  • Concordet D; INTHERES, Université de Toulouse, INRA, ENVT, Toulouse Cedex 3, France.
  • Djerada Z; Department de Pharmacologie Médicale, CHU Reims, EA3801, SFR Cap-Santé, Université de Reims, Reims, France.
  • Bouchet S; Laboratoire de Pharmacologie et Toxicologie, Service de Pharmacologie Médicale, CHU Pellegrin, Bordeaux, France.
  • Solas C; INSERM U1219, Bordeaux Cedex, France.
  • Mériglier E; Laboratoire de pharmacocinétique et Toxicologie, CHU Timone, Marseille, France.
  • Bonnet F; Service de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, CHU de Bordeaux, Bordeaux, France.
  • Mourvillier B; Service de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, CHU de Bordeaux, Bordeaux, France.
  • Ruiz S; Médecine Intensive Réanimation Polyvalente, CHU Reims, EA 4684 cardiovir, Université de Reims, Reims, France.
  • Martin-Blondel G; Service de Réanimation Rangueil, CHU de Toulouse, Toulouse Cedex 9, France.
  • Epaulard O; Service des Maladies Infectieuses et Tropicales, CHU de Toulouse, Toulouse Cedex 9, France.
  • Schwebel C; UMR INSERM/CNRS 1043, Centre de Physiopathologie Toulouse Purpan, Toulouse Cedex 9, France.
  • Gautier-Veyret E; Service des Maladies Infectieuses et Tropicales, 38000 CHU Grenoble Alpes, Grenoble, France.
  • Gandia P; Fédération d'Infectiologie Multidisciplinaire de l'Arc Alpin, Université Grenoble Alpes, Grenoble, France.
Clin Pharmacol Ther ; 109(4): 1030-1033, 2021 04.
Article em En | MEDLINE | ID: mdl-33547636
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Plasma / Ligação Proteica / Lopinavir / Tratamento Farmacológico da COVID-19 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Plasma / Ligação Proteica / Lopinavir / Tratamento Farmacológico da COVID-19 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2021 Tipo de documento: Article