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The tertiary oxime monoisonitrosoacetone penetrates the brain, reactivates inhibited acetylcholinesterase, and reduces mortality and morbidity following lethal sarin intoxication in guinea pigs.
Shih, Tsung-Ming; Oyler, Benjamin L; Capacio, Benedict R; Koplovitz, Irwin.
Afiliação
  • Shih TM; Medical Toxicology Research Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA. Electronic address: tsungming.a.shih.civ@mail.mil.
  • Oyler BL; Medical Toxicology Research Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA. Electronic address: benjamin.oyler@nih.gov.
  • Capacio BR; Medical Toxicology Research Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA. Electronic address: benedict.r.capacio.civ@mail.mil.
  • Koplovitz I; Medical Toxicology Research Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA. Electronic address: irvman30@comcast.net.
Toxicol Appl Pharmacol ; 415: 115443, 2021 03 15.
Article em En | MEDLINE | ID: mdl-33548273
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Acetilcolinesterase / Sarina / Encéfalo / Reativadores da Colinesterase / Intoxicação por Organofosfatos / Antídotos Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oximas / Acetilcolinesterase / Sarina / Encéfalo / Reativadores da Colinesterase / Intoxicação por Organofosfatos / Antídotos Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2021 Tipo de documento: Article