Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation.

Abbasi, Maryam; Amanlou, Massoud; Aghaei, Mahmoud; Hassanzadeh, Farshid; Sadeghi-Aliabadi, Hojjat

Abbasi, Maryam; Amanlou, Massoud; Aghaei, Mahmoud; Hassanzadeh, Farshid; Sadeghi-Aliabadi, Hojjat.

Afiliação

Abbasi M; Department of Medicinal Chemistry, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Amanlou M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Aghaei M; Department of Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Hassanzadeh F; Department of Medicinal Chemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Sadeghi-Aliabadi H; Department of Medicinal Chemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Anticancer Agents Med Chem ; 21(18): 2583-2591, 2021.

Article em En | MEDLINE | ID: mdl-33563187

Assuntos

Antineoplásicos/farmacologia; Proteínas de Choque Térmico HSP90/antagonistas & inibidores; Simulação de Dinâmica Molecular; Antineoplásicos/síntese química; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Avaliação Pré-Clínica de Medicamentos; Ensaios de Seleção de Medicamentos Antitumorais; Proteínas de Choque Térmico HSP90/metabolismo; Humanos; Estrutura Molecular

Palavras-chave

ATPase inhibition assay; Hsp90 inhibitors; MTT assay; aminobenzimidazole; molecular docking; molecular dynamic simulation; western blot.

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP90 / Simulação de Dinâmica Molecular / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Anticancer Agents Med Chem Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google