Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase.
Biosci Biotechnol Biochem
; 85(1): 126-133, 2021 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-33577666
ABSTRACT
Pyricularia oryzae is one of the most devastating plant pathogens in the world. This fungus produces several secondary metabolites including the phytotoxin pyriculols, which are classified into 2 types aldehyde form (pyriculol and pyriculariol) and alcohol form (dihydropyriculol and dihydropyriculariol). Although interconversion between the aldehyde form and alcohol form has been predicted, and the PYC10 gene for the oxidation of alcohol form to aldehyde is known, the gene responsible for the reduction of aldehyde to alcohol form is unknown. Furthermore, previous studies have predicted that alcohol analogs are biosynthesized via aldehyde analogs. Herein, we demonstrated that an aldo/keto reductase PYC7 is responsible for the reduction of aldehyde to alcohol congeners. The results indicate that aldehyde analogs are biosynthesized via alcohol analogs, contradicting the previous prediction. The results suggest that P. oryzae controls the amount of pyriculol analogs using two oxidoreductases, PYC7 and PYC10, thereby controlling the bioactivity of the phytotoxin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
8_ODS3_consumo_sustancias_psicoactivas
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
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Benzaldeídos
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Aldeído Redutase
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Álcoois Graxos
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Micotoxinas
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Ano de publicação:
2021
Tipo de documento:
Article