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Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice.
Kurach, Lukasz; Kulczycka-Mamona, Sylwia; Kowalczyk, Joanna; Skalicka-Wozniak, Krystyna; Boguszewska-Czubara, Anna; El Sayed, Nesrine; Osmani, Mitat; Iwaniak, Karol; Budzynska, Barbara.
Afiliação
  • Kurach L; Independent Laboratory of Behavioral Studies, Medical University of Lublin, 4A Chodzki Str., 20-093 Lublin, Poland.
  • Kulczycka-Mamona S; Department of Applied Pharmacy, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
  • Kowalczyk J; Department of Applied Pharmacy, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
  • Skalicka-Wozniak K; Independent Laboratory of Natural Products Chemistry, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
  • Boguszewska-Czubara A; Department of Medicinal Chemistry, Medical University of Lublin, 4A Chodzki Str., 20-093 Lublin, Poland.
  • El Sayed N; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  • Osmani M; Department of Pharmacy, University of Pristina, St. Bulevardi i Dëshmorëve, 10000 Pristina, Kosovo.
  • Iwaniak K; Department of Applied Pharmacy, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
  • Budzynska B; Independent Laboratory of Behavioral Studies, Medical University of Lublin, 4A Chodzki Str., 20-093 Lublin, Poland.
Int J Mol Sci ; 22(4)2021 Feb 10.
Article em En | MEDLINE | ID: mdl-33579030
Neuroinflammation plays an essential role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. Although coumarins have been shown to improve cognitive function in animal models and exert anti-inflammatory effects in cell cultures, the exact mechanism of their neuroprotective effects has not yet been fully elucidated. The present study aimed to investigate the neuroprotective effects of xanthotoxin (furanocoumarin) and umbelliferone (simple coumarin) in lipopolysaccharide-induced cognitive dysfunction in mice. For evaluation memory and learning processes, a passive avoidance test was used. Furthermore, acetylcholinesterase level and impact on the tumor necrosis factor α, interleukin 10 levels in the whole brain, and cyclooxygenase-II in hippocampus was established. Subchronic administration of both coumarins (15 mg/kg) enhanced the learning and memory function, but only the xanthotoxin improved cognitive processes impaired by lipopolysaccharide (0.8 mg/kg) administration. Behavioral results stay in line with acetylcholinesterase level in the brain. A statistically significant decrease in the level of tumor necrosis factor α and cyclooxygenase-II in lipopolysaccharide-treated rodents after coumarins' administration was observed. Together, our findings demonstrate that both coumarins improved cognitive functions, but only xanthotoxin significantly enhanced the learning and memory function and reduced the level of acetylcholinesterase in lipopolysaccharide-treated mice. This effect may suggest that only furanocoumarin-xanthotoxin attenuates neuroinflammation and enhances cholinergic neurotransmission, thus it can be a potential remedy with procognitive potential effective in treatment of neuroinflammatory disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Umbeliferonas / Cognição / Fármacos Neuroprotetores / Amnésia / Metoxaleno Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Umbeliferonas / Cognição / Fármacos Neuroprotetores / Amnésia / Metoxaleno Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article