Study on the correlation between urinary retinol-binding protein and nonalcoholic fatty liver disease.
J Med Biochem
; 40(1): 86-91, 2021 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-33584144
ABSTRACT
BACKGROUND:
Nonalcoholic fatty liver disease (NAFLD) affects human health worldwide. Our objective was to explore the correlation between urinary retinol-binding protein (URBP) and NAFLD.METHODS:
This cross-sectional study included 445 NAFLD patients and 911 healthy controls. The URBP level and other parameters were measured.RESULTS:
The URBP level (expressed by the RBP/creatinine ratio) was higher in the NAFLD patients compared with the non-NAFLD patients. The urinary RBP/creatinine ratio was an independent risk factor for NAFLD after univariate and multivariate regression analysis, with the or values of 2.271 (1.795-2.872, P < 0.001) and 2.338 (1.775-3.080, P < 0.001), respectively. The prevalence of the urinary RBP/creatinine ratio (groups 1, 2, 3, 4) was 20.0%, 17.3%, 27.3%, and 35.4%, respectively (P < 0.001), and the prevalence of NAFLD in the high urinary RBP/creatinine ratio group was significantly higher than that in the low urinary RBP/creatinine ratio group.CONCLUSIONS:
Our results revealed that the urinary RBP/creatinine ratio was an independent risk factor for NAFLD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Med Biochem
Ano de publicação:
2021
Tipo de documento:
Article