Combined Effect of the Preparation Method and Compression on the Physical Stability and Dissolution Behavior of Melt-Quenched Amorphous Celecoxib.

Be Rzins, Ka Rlis; Fraser-Miller, Sara J; Di, Rong; Liu, Jingwen; Peltonen, Leena; Strachan, Clare J; Rades, Thomas; Gordon, Keith C

Be Rzins, Ka Rlis; Fraser-Miller, Sara J; Di, Rong; Liu, Jingwen; Peltonen, Leena; Strachan, Clare J; Rades, Thomas; Gordon, Keith C.

Afiliação

Be Rzins KR; The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand.
Fraser-Miller SJ; The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand.
Di R; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
Liu J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
Peltonen L; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.
Strachan CJ; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.
Rades T; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
Gordon KC; The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand.

Mol Pharm ; 18(3): 1408-1418, 2021 03 01.

Article em En | MEDLINE | ID: mdl-33586988

Assuntos

Celecoxib/química; Varredura Diferencial de Calorimetria/métodos; Química Farmacêutica/métodos; Cristalização/métodos; Composição de Medicamentos/métodos; Estabilidade de Medicamentos; Transição de Fase/efeitos dos fármacos; Solubilidade/efeitos dos fármacos; Espectroscopia de Infravermelho com Transformada de Fourier/métodos; Análise Espectral Raman/métodos; Difração de Raios X/métodos

Palavras-chave

amorphous drugs; celecoxib; compression-induced destabilization; dissolution; low-frequency Raman spectroscopy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Celecoxib Idioma: En Revista: Mol Pharm Ano de publicação: 2021 Tipo de documento: Article

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