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Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
Chelko, Stephen P; Keceli, Gizem; Carpi, Andrea; Doti, Nunzianna; Agrimi, Jacopo; Asimaki, Angeliki; Beti, Carlos Bueno; Miyamoto, Matthew; Amat-Codina, Nuria; Bedja, Djahida; Wei, An-Chi; Murray, Brittney; Tichnell, Crystal; Kwon, Chulan; Calkins, Hugh; James, Cynthia A; O'Rourke, Brian; Halushka, Marc K; Melloni, Edon; Saffitz, Jeffrey E; Judge, Daniel P; Ruvo, Menotti; Kitsis, Richard N; Andersen, Peter; Di Lisa, Fabio; Paolocci, Nazareno.
Afiliação
  • Chelko SP; Department of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA. stephen.chelko@med.fsu.edu npaoloc1@jhmi.edu.
  • Keceli G; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Carpi A; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Doti N; Department of Biomedical Sciences, University of Padova, Padova 35122, Italy.
  • Agrimi J; Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.
  • Asimaki A; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Beti CB; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London WC1E 6BS, UK.
  • Miyamoto M; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London WC1E 6BS, UK.
  • Amat-Codina N; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Bedja D; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Wei AC; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Murray B; Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia.
  • Tichnell C; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Kwon C; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Calkins H; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • James CA; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • O'Rourke B; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Halushka MK; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Melloni E; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Saffitz JE; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Judge DP; Department of Medicine, University of Genova, Genova 16126, Italy.
  • Ruvo M; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 20115, USA.
  • Kitsis RN; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  • Andersen P; Medical University of South Carolina, Charleston, SC 29425, USA.
  • Di Lisa F; Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.
  • Paolocci N; Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Sci Transl Med ; 13(581)2021 02 17.
Article em En | MEDLINE | ID: mdl-33597260
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Calpaína / Miócitos Cardíacos / Fator de Indução de Apoptose / Cardiomiopatias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Transl Med Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Calpaína / Miócitos Cardíacos / Fator de Indução de Apoptose / Cardiomiopatias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Transl Med Ano de publicação: 2021 Tipo de documento: Article