Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain.
Arch Physiol Biochem
; 129(4): 901-912, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-33618606
ABSTRACT
AIM:
To validate neuroprotective effect of pectin against neuropathic pain in diabetic rodents. MATERIAL ANDMETHOD:
Pectin was isolated and characterised from different sources to validate its neuroprotective effect against T2DM associated neuropathic pain. The antioxidant activity of pectins was done by the DPPH method. Type-2 diabetes mellitus (T2DM) was induced in Wistar albino rats by high-fat diet and high-fat emulsion feeding for 2 weeks followed by a single i.p. of Sterptozotocin in 3rd week. The animals were grouped as positive control and Citrus sinensis (L.) Osbeck peel pectin (CSL-OP) as test group and treated for the next 4 weeks. Body weight and blood glucose were measured up to 8 weeks; however, behavioural assessment was done at the end of 5th to 8th week.RESULT:
CSL-OP restored the reduced body weight and elevated blood glucose with increased pain threshold and improved walking performance.CONCLUSION:
CSL-OP prevented progression of early diabetic neuropathy with anti-oxidant activity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Fármacos Neuroprotetores
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Diabetes Mellitus Experimental
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Diabetes Mellitus Tipo 2
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Neuropatias Diabéticas
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Neuralgia
Limite:
Animals
Idioma:
En
Revista:
Arch Physiol Biochem
Ano de publicação:
2023
Tipo de documento:
Article