Copper-Catalyzed Radical 1,2-Carbotrifluoromethylselenolation of Alkenes under Ambient Conditions.
Org Lett
; 23(5): 1945-1949, 2021 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-33625234
ABSTRACT
We have described a copper-catalyzed radical 1,2-carbotrifluoromethylselenolation of alkenes using the readily available alkyl halides and (Me4N)SeCF3 salt. Critical to the success is the use of a proline-based N,N,P-ligand to enhance the reducing capability of copper for easy conversion of diverse alkyl halides to the corresponding radicals via a single-electron transfer process. The reaction features a broad substrate scope, including various mono-, di-, and trisubstituted alkenes with many functional groups.
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01-internacional
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MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2021
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Article