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A comparison of local recurrence and resection margins for stage I primary cutaneous malignant melanomas.
Zeitels, J; LaRossa, D; Hamilton, R; Synnestvedt, M; Schultz, D.
Afiliação
  • Zeitels J; Department of Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.
Plast Reconstr Surg ; 81(5): 688-93, 1988 May.
Article em En | MEDLINE | ID: mdl-3362987
A retrospective review of 552 patients with clinical stage I primary cutaneous malignant melanomas was undertaken comparing margins of resection and local recurrence between 1966 and 1981. The overall local recurrence rate was 8 per 552 (1.45 percent). We observed no instances of local recurrence in lesions less than 1.40 mm thick with resection margins of at least 1 cm. A comparison of resection margins greater than 2 cm versus less than 2 cm for lesions less than 1.00 mm thick showed no difference at the 0.05 level of significance for local recurrence (0 per 228 versus 2 per 154; 1.3 percent) or survival. While narrower margins of resection for thinner, low-risk stage I malignant melanomas appear safe, the exact minimum margin of resection needed to satisfy both oncologic and cosmetic considerations, whether 1 or 2 cm, will need to be determined by a large prospective, randomized study.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Melanoma / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Plast Reconstr Surg Ano de publicação: 1988 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Melanoma / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Plast Reconstr Surg Ano de publicação: 1988 Tipo de documento: Article