Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection.
Curr Issues Mol Biol
; 42: 635-686, 2021.
Article
em En
| MEDLINE
| ID: mdl-33640867
ABSTRACT
Both the development of the mammalian innate immune system and the antagonistic strategies acquired by alphaherpesviruses to dismantle it have been shaped by co-evolving virus-host interactions over millions of years. Here, we review mechanisms employed by mammalian cells to detect pathogen molecules, such as viral glycoproteins and nucleic acids, and induce innate immune signaling upon infection with alphaherpesviruses. We further explore strategies acquired by these viruses to bypass immune detection and activation, thereby supporting virus replication and spread. Finally, we discuss the contributions of advanced 'omics' and microscopy methods to these discoveries in immune signaling and highlight emerging technologies that can help to further our understanding of the dynamic interplay between host innate immune responses and virus immune evasion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alphaherpesvirinae
/
Infecções por Herpesviridae
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Interações Hospedeiro-Patógeno
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Evasão da Resposta Imune
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Imunidade Inata
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Issues Mol Biol
Ano de publicação:
2021
Tipo de documento:
Article