[Histopathologic grading of breast cancer; large variation with major consequences?] / Histopathologische gradering van het mammacarcinoom.
Ned Tijdschr Geneeskd
; 1642021 01 14.
Article
em Nl
| MEDLINE
| ID: mdl-33651508
ABSTRACT
The pathologist's assessment of tumor tissue plays a critical role in therapeutic decision-making in early-stage invasive breast cancer. In daily practice, however, there appears to be considerable variation in grading between the different Dutch pathology laboratories and between individual pathologists within the same laboratory. This underlines the need to standardize grading by pathologists as much as possible in order to minimize the risk of a worse outcome for patients due to under-treatment and of unnecessary toxicity from over-treatment. Therefore, two initiatives were launched, i.e. laboratory-specific feedback reports and an e-learning module in which pathologists were trained in grading of invasive breast cancer. While these initiatives have yielded encouraging results, the overall variation in grading remains significant. Awareness of this variation, and of the inherent difficulties of subjective grading, among the various clinicians involved in breast cancer management, is therefore of utmost importance to improve clinical decision-making for patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Patologia Clínica
/
Neoplasias da Mama
/
Detecção Precoce de Câncer
/
Gradação de Tumores
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Female
/
Humans
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Ano de publicação:
2021
Tipo de documento:
Article