Investigations on Synergistic and Antioxidant Actions of Medicinal Plant- Based Biosynthesis of Zinc Oxide Nanoparticles Against E.coli and K. pneumonia Bacteria.
Comb Chem High Throughput Screen
; 25(7): 1200-1206, 2022.
Article
em En
| MEDLINE
| ID: mdl-33653240
ABSTRACT
INTRODUCTION:
Bacterial resistance to multiple drugs is increasing at an alarming rate in the current era and nanotechnology is one of the effective and novel approaches to overcome drug resistance.METHODS:
Zinc Oxide Nanoparticles (ZnO NPs) have stronger antibacterial activity and are regarded as bio-safe nanomaterial. The aim of the present study is to synthesize the ZnO NPs using Aloe vera leaves extract and to investigate the synergistic effects and antioxidant actions of biosynthesized ZnO NPs against gram-negative bacteria E.coli and K. pneumoniae. The synergistic effect of ß-lactam antibiotics (meropenem and ciprofloxacin) was tested along with ZnO NPs using Kirby's disc diffusion assay. The antioxidant activity was investigated by α, α-diphenyl-ß- picrylhydrazyl (DPPH) method.RESULTS:
Results of the study revealed that the antibacterial activity of the selected antibiotics was much enhanced by ZnO NPs than the antibiotics alone. The resistant antibiotic (ciprofloxacin) became sensitive when combined with ZnO NPs. The antioxidant activity reveals that biosynthesized ZnO NPs possess significantly higher (p<0.05) antioxidant activity (77%).CONCLUSION:
The findings reveal that biosynthesized ZnO NPs have a much more eco-friendly approach. It can act as a strong potentiator of ß-lactam antibiotics and put forward the possibility to use them effectively in targeted drug delivery, pharmaceuticals and biomedical fields.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Pneumonia
/
Óxido de Zinco
/
Nanopartículas
/
Nanopartículas Metálicas
Idioma:
En
Revista:
Comb Chem High Throughput Screen
Ano de publicação:
2022
Tipo de documento:
Article