Posttranscriptional regulation of de novo lipogenesis by glucose-induced O-GlcNAcylation.

Tan, Wei; Jiang, Pei; Zhang, Wanjun; Hu, Zhaohua; Lin, Shaofeng; Chen, Lulu; Li, Yingge; Peng, Changmin; Li, Zhuqing; Sun, Aihua; Chen, Yali; Zhu, Wenge; Xue, Yu; Yao, Yi; Li, Xiangpan; Song, Qibin; He, Fuchu; Qin, Weijie; Pei, Huadong

Tan, Wei; Jiang, Pei; Zhang, Wanjun; Hu, Zhaohua; Lin, Shaofeng; Chen, Lulu; Li, Yingge; Peng, Changmin; Li, Zhuqing; Sun, Aihua; Chen, Yali; Zhu, Wenge; Xue, Yu; Yao, Yi; Li, Xiangpan; Song, Qibin; He, Fuchu; Qin, Weijie; Pei, Huadong.

Afiliação

Tan W; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science, 2300 Eye Street, N.W., Washington, DC 20037, USA.
Jiang P; State Key Laboratory of Proteomics, National Center for Protein Sciences - Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China; Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430062, China.
Zhang W; State Key Laboratory of Proteomics, National Center for Protein Sciences - Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China.
Hu Z; Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430062, China.
Lin S; Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Chen L; Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430062, China; GW Cancer Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Li Y; Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430062, China; GW Cancer Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Peng C; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science, 2300 Eye Street, N.W., Washington, DC 20037, USA; GW Cancer Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Li Z; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science, 2300 Eye Street, N.W., Washington, DC 20037, USA; GW Cancer Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Sun A; State Key Laboratory of Proteomics, National Center for Protein Sciences - Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China.
Chen Y; State Key Laboratory of Proteomics, National Center for Protein Sciences - Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China.
Zhu W; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science, 2300 Eye Street, N.W., Washington, DC 20037, USA; GW Cancer Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Xue Y; Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Yao Y; Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430062, China.
Li X; Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430062, China.
Song Q; Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430062, China.
He F; State Key Laboratory of Proteomics, National Center for Protein Sciences - Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China. Electronic address: hefc@bmi.ac.cn.
Qin W; State Key Laboratory of Proteomics, National Center for Protein Sciences - Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China. Electronic address: aunp_dna@126.com.
Pei H; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science, 2300 Eye Street, N.W., Washington, DC 20037, USA; GW Cancer Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA. Electronic ad

Mol Cell ; 81(9): 1890-1904.e7, 2021 05 06.

Article em En | MEDLINE | ID: mdl-33657401

Assuntos

Neoplasias da Mama/metabolismo; Glucose/metabolismo; Lipogênese; Processamento de Proteína Pós-Traducional; Proteínas Serina-Treonina Quinases/metabolismo; Transporte Ativo do Núcleo Celular; Animais; Neoplasias da Mama/genética; Proliferação de Células; Feminino; Glicosilação; Células HEK293; Humanos; Células MCF-7; Camundongos Nus; N-Acetilglucosaminiltransferases/genética; N-Acetilglucosaminiltransferases/metabolismo; Proteínas Serina-Treonina Quinases/genética; Precursores de RNA/genética; Precursores de RNA/metabolismo; Splicing de RNA; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transdução de Sinais; Carga Tumoral; alfa Carioferinas/genética; alfa Carioferinas/metabolismo; beta Carioferinas/genética; beta Carioferinas/metabolismo

Palavras-chave

O-GlcNAcylation; SRPK2; lipid synthesis; nuclear import

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Processamento de Proteína Pós-Traducional / Proteínas Serina-Treonina Quinases / Lipogênese / Glucose Limite: Animals / Female / Humans Idioma: En Revista: Mol Cell Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google