Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea.
Biomark Med
; 15(5): 323-330, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33666516
ABSTRACT
Aim:
Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered suggesting regulatory mechanisms. Our aim was to investigate complement factor H (CFH) and clusterin, two important complement regulators in OSA. Materials &methods:
We analyzed clusterin and CFH levels in plasma of 86 patients with OSA and 33 control subjects.Results:
There was no difference in CFH levels between patients (1099.4/784.6-1570.5/µg/ml) and controls (1051.4/652.0-1615.1/µg/ml, p = 0.72). Clusterin levels were higher in patients with OSA (309.7/217.2-763.2/µg/ml vs 276.1/131.0-424.3/µg/ml, p = 0.048) with a trend for a positive correlation with disease severity (p = 0.073).Conclusion:
Increase in clusterin levels may be protective in OSA by blocking the MAC formation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Apneia Obstrutiva do Sono
/
Clusterina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Biomark Med
Ano de publicação:
2021
Tipo de documento:
Article