The Multi-Targeting Ligand ST-2223 with Histamine H3 Receptor and Dopamine D2/D3 Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and Brain Oxidative Stress in Mice.

Eissa, Nermin; Venkatachalam, Karthikkumar; Jayaprakash, Petrilla; Falkenstein, Markus; Dubiel, Mariam; Frank, Annika; Reiner-Link, David; Stark, Holger; Sadek, Bassem

The Multi-Targeting Ligand ST-2223 with Histamine H₃ Receptor and Dopamine D₂/D₃ Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and Brain Oxidative Stress in Mice.

Eissa, Nermin; Venkatachalam, Karthikkumar; Jayaprakash, Petrilla; Falkenstein, Markus; Dubiel, Mariam; Frank, Annika; Reiner-Link, David; Stark, Holger; Sadek, Bassem.

Afiliação

Eissa N; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Venkatachalam K; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Jayaprakash P; Department of Applied Sciences, College of Arts and Sciences, Abu Dhabi University, Al Ain P.O. Box 59911, United Arab Emirates.
Falkenstein M; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Dubiel M; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Frank A; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Reiner-Link D; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr.1, 40225 Düsseldorf, Germany.
Sadek B; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr.1, 40225 Düsseldorf, Germany.

Int J Mol Sci ; 22(4)2021 Feb 16.

Article em En | MEDLINE | ID: mdl-33669336

Assuntos

Transtorno do Espectro Autista/tratamento farmacológico; Encéfalo/metabolismo; Antagonistas dos Receptores de Dopamina D2/administração & dosagem; Asseio Animal/efeitos dos fármacos; Antagonistas dos Receptores Histamínicos H3/administração & dosagem; Estresse Oxidativo/efeitos dos fármacos; Receptores de Dopamina D3/antagonistas & inibidores; Animais; Ansiedade/tratamento farmacológico; Encéfalo/efeitos dos fármacos; Modelos Animais de Doenças; Antagonistas dos Receptores de Dopamina D2/metabolismo; Células HEK293; Antagonistas dos Receptores Histamínicos H3/metabolismo; Humanos; Ligantes; Locomoção/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Receptores de Dopamina D2/metabolismo; Receptores de Dopamina D3/metabolismo; Receptores Histamínicos H3/metabolismo

Palavras-chave

BTBR mice; anxiety; autistic spectrum disorder; dopamine D2/D3R antagonist; histamine H3 receptor antagonist; oxidative stress; repetitive and restricted behavior

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Estresse Oxidativo / Receptores de Dopamina D3 / Antagonistas dos Receptores Histamínicos H3 / Antagonistas dos Receptores de Dopamina D2 / Transtorno do Espectro Autista / Asseio Animal Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article

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