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Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase.
Gregor, Jirí; Radilová, Katerina; Brynda, Jirí; Fanfrlík, Jindrich; Konvalinka, Jan; Kozísek, Milan.
Afiliação
  • Gregor J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.
  • Radilová K; First Faculty of Medicine, Charles University, Katerinská 1660/32, 12108 Prague 2, Czech Republic.
  • Brynda J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.
  • Fanfrlík J; First Faculty of Medicine, Charles University, Katerinská 1660/32, 12108 Prague 2, Czech Republic.
  • Konvalinka J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.
  • Kozísek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 16610 Prague 6, Czech Republic.
Molecules ; 26(4)2021 Feb 14.
Article em En | MEDLINE | ID: mdl-33673017
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Piridinas / Pirimidinas / Pirróis / Proteínas Virais / RNA Polimerase Dependente de RNA / Subunidades Proteicas / Farmacorresistência Viral Tipo de estudo: Clinical_trials Idioma: En Revista: Molecules Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Piridinas / Pirimidinas / Pirróis / Proteínas Virais / RNA Polimerase Dependente de RNA / Subunidades Proteicas / Farmacorresistência Viral Tipo de estudo: Clinical_trials Idioma: En Revista: Molecules Ano de publicação: 2021 Tipo de documento: Article