Discovery of novel indole-1,2,4-triazole derivatives as tubulin polymerization inhibitors.

Wu, Meng-Ke; Man, Ruo-Jun; Liao, Yan-Juan; Zhu, Hai-Liang; Zhou, Zhu-Gui

Wu, Meng-Ke; Man, Ruo-Jun; Liao, Yan-Juan; Zhu, Hai-Liang; Zhou, Zhu-Gui.

Afiliação

Wu MK; Guangxi Biological Polysaccharide Separation, Purification and Modification Research Platform, Guangxi University for Nationalities, Nanning, China.
Man RJ; Guangxi Biological Polysaccharide Separation, Purification and Modification Research Platform, Guangxi University for Nationalities, Nanning, China.
Liao YJ; Guangxi Biological Polysaccharide Separation, Purification and Modification Research Platform, Guangxi University for Nationalities, Nanning, China.
Zhu HL; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Zhou ZG; College of Chemistry and Chemical Engineering, Guangxi Key Laboratory of Polysaccharide Materials and Modifications, Guangxi University for Nationalities, Nanning, China.

Drug Dev Res ; 82(7): 1008-1020, 2021 11.

Article em En | MEDLINE | ID: mdl-33675542

Assuntos

Antineoplásicos; Moduladores de Tubulina; Antineoplásicos/química; Antineoplásicos/farmacologia; Apoptose; Linhagem Celular Tumoral; Proliferação de Células; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Indóis/farmacologia; Simulação de Acoplamento Molecular; Estrutura Molecular; Relação Estrutura-Atividade; Triazóis; Moduladores de Tubulina/química; Moduladores de Tubulina/farmacologia

Palavras-chave

colchicine-binding site; indole-1,2,4-triazole; microtubules; molecular docking

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Moduladores de Tubulina / Antineoplásicos Limite: Humans Idioma: En Revista: Drug Dev Res Ano de publicação: 2021 Tipo de documento: Article

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