Is GDF-15 level associated with gestational diabetes mellitus and adverse perinatal outcomes?
Taiwan J Obstet Gynecol
; 60(2): 221-224, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33678319
ABSTRACT
OBJECTIVE:
Growth differentiation factor-15 (GDF-15), the new member of transforming growth factor (TGF)-beta family, is released as a response of oxidative stress, inflammation and tissue injury. We aimed to determine GDF-15 levels in patients with Gestational Diabetes Mellitus (GDM) and the relation between GDF-15 and adverse perinatal outcomes. MATERIALS ANDMETHODS:
Forty pregnant women with GDM (receiving diet and insulin therapy) and forty healthy pregnant women as control group participated in this current study. GDF- 15 levels were analyzed by enzyme-linked immunosorbent assess kit.RESULTS:
The median serum GDF-15 level was measured higher in patients with GDM, and it was statistically meaningful (p 0.000). Logistic regression analysis indicated that with the increase of GDF-15 level, the risk of GDM diseases increases as well. (P 0.001, OR = 1.009; 95% CI = 1.003-1.014). There were no differences between GDF-15 levels and perinatal outcomes.CONCLUSION:
We concluded that higher GDF-15 levels are related to GDM in the third trimester. The optimal GDF-15 cut-off value was measured as 326 pg/ml for the diagnosis of GDM with 70% sensitivity and 60% specificity in our study. Further studies are needed to show the significance of GDF-15 as a biomarker for the disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terceiro Trimestre da Gravidez
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Resultado da Gravidez
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Diabetes Gestacional
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Fator 15 de Diferenciação de Crescimento
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Taiwan J Obstet Gynecol
Ano de publicação:
2021
Tipo de documento:
Article