Antigen-Specific Treatment Modalities in MS: The Past, the Present, and the Future.
Front Immunol
; 12: 624685, 2021.
Article
em En
| MEDLINE
| ID: mdl-33679769
ABSTRACT
Antigen-specific therapy for multiple sclerosis may lead to a more effective therapy by induction of tolerance to a wide range of myelin-derived antigens without hampering the normal surveillance and effector function of the immune system. Numerous attempts to restore tolerance toward myelin-derived antigens have been made over the past decades, both in animal models of multiple sclerosis and in clinical trials for multiple sclerosis patients. In this review, we will give an overview of the current approaches for antigen-specific therapy that are in clinical development for multiple sclerosis as well provide an insight into the challenges for future antigen-specific treatment strategies for multiple sclerosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Vacinas
/
Dessensibilização Imunológica
/
Vacinação
/
Transferência Adotiva
/
Esclerose Múltipla
/
Proteínas da Mielina
Tipo de estudo:
Prognostic_studies
/
Sysrev_observational_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Front Immunol
Ano de publicação:
2021
Tipo de documento:
Article