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MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.
Uemura, Kentaro; Sasaki, Michihito; Sanaki, Takao; Toba, Shinsuke; Takahashi, Yoshimasa; Orba, Yasuko; Hall, William W; Maenaka, Katsumi; Sawa, Hirofumi; Sato, Akihiko.
Afiliação
  • Uemura K; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.
  • Sasaki M; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Sanaki T; Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
  • Toba S; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Takahashi Y; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.
  • Orba Y; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Hall WW; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.
  • Maenaka K; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Sawa H; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Sato A; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Sci Rep ; 11(1): 5376, 2021 03 08.
Article em En | MEDLINE | ID: mdl-33686154
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Descoberta de Drogas / Engenharia Celular / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Modelos Biológicos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Descoberta de Drogas / Engenharia Celular / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Modelos Biológicos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article