Organofluorine Hydrazone Derivatives as Multifunctional Anti-Alzheimer's Agents with CK2 Inhibitory and Antioxidant Features.
ChemMedChem
; 16(12): 1927-1932, 2021 06 17.
Article
em En
| MEDLINE
| ID: mdl-33713036
ABSTRACT
A set of novel hydrazone derivatives were synthesized and analyzed for their biological activities. The compounds were tested for their inhibitory effect on the phosphorylating activity of the protein kinase CK2, and their antioxidant activity was also determined in three commonly used assays. The hydrazones were evaluated for their radical scavenging against the DPPH, ABTS and peroxyl radicals. Several compounds have been identified as good antioxidants as well as potent protein kinase CK2 inhibitors. Most hydrazones containing a 4-N(CH3 )2 residue or perfluorinated phenyl rings showed high activity in the radical-scavenging assays and possess nanomolar IC50 values in the kinase assays.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caseína Quinase II
/
Inibidores de Proteínas Quinases
/
Doença de Alzheimer
/
Fluorocarbonos
/
Hidrazonas
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
ChemMedChem
Ano de publicação:
2021
Tipo de documento:
Article